Elke Schaeffeler Selected Research

Enzymes

1/2022	Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma.
12/2014	Impact of counterbalance between macrophage migration inhibitory factor and its inhibitor Gremlin-1 in patients with coronary artery disease.
3/2005	Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.

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Elke Schaeffeler Research Topics

Disease

21	Neoplasms (Cancer) 01/2024 - 08/2009
13	Renal Cell Carcinoma (Grawitz Tumor) 01/2024 - 10/2015
11	Crohn Disease (Crohn's Disease) 03/2013 - 10/2005
8	Coronary Artery Disease (Coronary Atherosclerosis) 12/2023 - 09/2008
6	Drug-Related Side Effects and Adverse Reactions 01/2021 - 01/2007
6	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2011
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2016 - 01/2007
5	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2023 - 03/2005
5	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2016
5	Acute Coronary Syndrome 11/2020 - 09/2008
4	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 12/2011
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 01/2016
3	Fibrosis (Cirrhosis) 01/2020 - 01/2016
3	Thrombosis (Thrombus) 01/2017 - 12/2014
2	Hyperbilirubinemia 01/2023 - 01/2018
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2023 - 09/2010
2	Alzheimer Disease (Alzheimer's Disease) 02/2021 - 10/2020
2	Liver Neoplasms (Liver Cancer) 01/2020 - 12/2014
2	Solitary Kidney 01/2019 - 01/2018
2	Ischemic Stroke 01/2018 - 01/2016
2	Cardiomyopathies (Cardiomyopathy) 01/2018 - 01/2016
2	Muscular Dystrophies (Muscular Dystrophy) 01/2018 - 01/2016
2	Atherosclerosis 01/2017 - 10/2015
2	Leukemia 01/2017 - 04/2013
2	Type 2 Diabetes Mellitus (MODY) 11/2015 - 09/2008
2	Diarrhea 05/2008 - 05/2008
2	Inflammation (Inflammations) 09/2006 - 12/2005
2	Ulcerative Colitis 12/2005 - 01/2003
2	Colitis 10/2005 - 01/2003
2	Hypertension (High Blood Pressure) 01/2005 - 06/2004
1	Disease Susceptibility (Diathesis) 10/2023
1	Hepatic Insufficiency 01/2023
1	Anovulation 11/2022
1	Genetic Predisposition to Disease (Genetic Predisposition) 05/2022
1	Memory Disorders (Memory Loss) 02/2021
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2021

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2011
8	Azathioprine (Imuran)FDA LinkGeneric 04/2013 - 10/2005
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2016
5	Messenger RNA (mRNA)IBA 01/2020 - 12/2011
5	2-mercaptopurineIBA 10/2016 - 01/2007
4	MicroRNAs (MicroRNA)IBA 12/2023 - 01/2016
4	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 01/2021 - 03/2012
4	Clopidogrel (Plavix)FDA Link 01/2020 - 09/2008
4	Cytochrome P-450 CYP3AIBA 01/2019 - 01/2005
4	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 04/2013 - 03/2005
3	NucleotidesIBA 01/2023 - 02/2007
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 09/2013
3	EnzymesIBA 01/2022 - 03/2005
3	Thioguanine (Tioguanine)FDA Link 01/2021 - 10/2005
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2021 - 01/2005
3	Tamoxifen FDA LinkGeneric 01/2020 - 01/2017
3	Phosphotransferases (Kinase)IBA 01/2017 - 02/2014
3	CationsIBA 12/2014 - 10/2009
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 12/2014 - 10/2002
3	Mesalamine (Mesalazine)FDA LinkGeneric 03/2013 - 02/2007
3	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 08/2009 - 03/2005
2	BilirubinIBA 01/2023 - 01/2018
2	Clomiphene (Clomifene)FDA LinkGeneric 11/2022 - 03/2012
2	LipidsIBA 10/2020 - 01/2019
2	Peptides (Polypeptides)IBA 01/2020 - 01/2011
2	Sorafenib (BAY 43-9006)FDA Link 01/2020 - 12/2014
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 01/2017
2	Organic Cation Transporter 1IBA 01/2020 - 02/2014
2	RNA (Ribonucleic Acid)IBA 12/2019 - 01/2018
2	4-hydroxy-N-desmethyltamoxifenIBA 01/2019 - 01/2017
2	Monocarboxylic Acid TransportersIBA 12/2018 - 09/2013
2	GadoliniumIBA 01/2018 - 01/2016
2	Metformin (Glucophage)FDA LinkGeneric 11/2015 - 02/2013
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2014 - 01/2013
2	DefensinsIBA 01/2009 - 09/2006
2	alpha-DefensinsIBA 01/2009 - 12/2005
2	Cytochrome P-450 CYP2C19IBA 09/2008 - 12/2005
2	Anti-Bacterial Agents (Antibiotics)IBA 05/2008 - 01/2003
2	Chloride Channels (Chloride Channel)IBA 04/2006 - 06/2004
2	SaltsIBA 04/2006 - 06/2004
1	Immune Checkpoint InhibitorsIBA 01/2024
1	AntibodiesIBA 01/2024
1	Carrier Proteins (Binding Protein)IBA 10/2023
1	Selective Estrogen Receptor Modulators (SERM)IBA 11/2022
1	Junctional Adhesion Molecule AIBA 05/2022
1	ThioredoxinsIBA 03/2022
1	Nicotinamide N-MethyltransferaseIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	N-nitroso-N-methyltyramine (NNMT)IBA 01/2022
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2022
1	Cholinergic Agents (Cholinergics)IBA 02/2021
1	Angiotensin Receptor AntagonistsIBA 02/2021
1	Amyloid beta-PeptidesIBA 02/2021
1	Valganciclovir FDA Link 01/2021
1	Interleukin-10 (Interleukin 10)IBA 01/2021

Therapy/Procedure

16	Therapeutics 01/2024 - 05/2008
4	Drug Therapy (Chemotherapy) 01/2023 - 03/2005
3	Aftercare (After-Treatment) 08/2009 - 03/2005
2	Precision Medicine 12/2021 - 01/2021
2	Percutaneous Coronary Intervention 11/2020 - 01/2018
2	Transplantation 10/2020 - 01/2019
1	Duration of Therapy 01/2023
1	Immunotherapy 01/2022
1	Organ Transplantation 01/2021